Nanotech for Neurological Health: Nasal Gel Innovations | InformativeBD

 

Indira Muzib Yallamalli , Arunakumari Dommaraju , and Ramji Ambedkar Yellamelli from the different institute of the india wrote a research article about Nanotech for Neurological Health: Nasal Gel Innovations, entitled " Intra nasal in-situ gel freighted with Nano naturaceuticals for neurological diseases – from bench to bed side"This research paper published by the International Journal of Bioscience |IJB an open access scholarly research journal on Biology, under the affiliation of the International Network For Natural Sciences |INNSpub, an open access multidisciplinary research journal publisher.

Abstract:

The treatment for acute or chronic neurodegenerative diseases is the most exigent aspect in many aspects, as the drug should cross the blood-brain barrier. At present many formulations have been developed for synthetic drugs to target the drug to the brain through various routes. Among them,the nasal route is one of the most prominent routes to target the drug to the brain, where the drug can bypass the BBB. There are many natural drugs, Phytoconstituents also available for the treatment of neurodegenerative diseases. Because of the many advantages like natural, safe, easily available, biocompatible, low cost, etc., of natural drugs over synthetic drugs, the researchers were focused on the development of the formulations of natural drugs for various diseases. But here, the challenging concept is the delivery of the active Phytoconstituents to the brain through the nasal route as the molecular weight of the drugs is rate limited. Among the nasal formulations, in-situ gel systems are the trending research work carrying. So the review was focused on the overview of the available Phytoconstituents to treat brain disorders and how the drugs target the brain through the nasal route. A brief about nasal anatomy, the pros and cons of nasal drug delivery and nasal in-situ gels was also noted. The review summarizes the available nanoformulations for the Phytoconstituents to target the drug to the brain through the nasal route.

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Introduction

Brian is a mesmerizing organ known for its entanglement. This fragile organ was protected by the skull structure outside and inside, which consists of mainly two protective barriers, namely the blood brain barrier (BBB) and the blood-cerebro spinal fluidbarrier (BCSF), which hinder the treatment strategiesendorsed for the therapeutic determination. Because of this fragility, the time period will be more for the development of CNS drugs than the NON-CNS drugs(Dong, 2018). The CNS disorders such as epilepsy, dementia, Parkinson's, Alzheimer's, brain tumors, meningitis, and brain tumors, can be managed by both natural and unnatural drug molecules but greatly depends upon the means of attaining higher drug levels at the targeting sites (Goyal D et al.,2017).However, the synthetic drug molecules have alow molecular weight compared to the natural one sand the research was expanded.

Presently the research on natural drugs is gaining much interest because of their bio-friendly nature and supremacy over synthetic drugs (Borris, R. P. 1996).Most natural molecules havea high molecular weight, so the physico chemical properties of the drug mainly domineer its ability to penetrate the drug through these barriers and to exhibit therapeutic outcomes(Yu et al., 2019). So the only option to target the drug molecules in the brain is bypassing the barriers. To by pass the drug molecules through these protective barriers of brain to present their therapeutic effect, the nasal route drug delivery is the only choice (Khanet al., 2017). There is scientific growth supporting nasal drug delivery owing to the fact that a confirmed concentration of drug can cross BBB. One more satisfaction of this route is that it delivers both intracellular and extra-cellular drug transport pathways to the CNS, which further depends on added factors like physico chemical properties of the drug and receptor spresent in the olfactory region.

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Source: Intra nasal in-situ gel freighted with Nanonaturaceuticals for neurological diseases – from bench to bed side