Jayaprakash Kuzhandaivel , Balamurugan Vadivel and Rajasekar Aruliah from the different institute of the india, wrote a research article about Green Synthesis: Silver Nanoparticles from Moringa oleifera, entitled, Antimicrobial and antioxidant properties of silver nanoparticles from Moringa oleifera gum: a green synthesis approach. This research paper published by the International Journal of Biosciences| IJB an open access scholarly research journal on Bioscience, under the affiliation of the International Network For Natural Sciences | INNSpub, an open access multidisciplinary research journal publisher.
Abstract
Plant gums have enormous medicinal potential and have been used in the pharmaceutical and biomedical fields. In the present investigation, Moringa oleifera gum (MOG) was collected, and its physical properties and phytochemical composition were investigated. Silver nanoparticles (AgNPs) were produced, and characterization was carried out using UV spectroscopic analysis and scanning electron microscopy (SEM). In this study, the standard method was used for the antioxidant assay and the antimicrobial test. The synthesized nanoparticles (NPs) have irregular shapes and no fixed geometry. The agglomerate shape resembles that of pebble-like structures. UV‒vis analysis proved the wavelength of the sample to be 350–470 nm. In antioxidant studies, the synthesized AgNPs exhibited significant DPPH radical scavenging activity values ranging from 21.15 ± 0.017 to 63.46± 0.03 g/mL at concentrations ranging from 100 to 500 g/mL. In an antimicrobial experiment, the maximum incubation zone was 18 mm by 100 µL of AgNPs synthesized from M. oleifera gum extract against S. typhi. P. aeruginosa expressed a 16 mm zone of incubation at 100 µL of AgNPs synthesized from M. oleifera gum. According to the findings of this study, AgNPs derived from M. oleifera gum can be employed as a lead chemical in the creation of an effective antimicrobial drug for the treatment of microbial infections. This research establishes the foundation for synthesizing AgNPs from M. oleifera gum and its powerful novel pharmacological applications.
Introduction
Plant gums have tremendous therapeutic importancein pharmaceutical preparations such as tablets,lotions, suspensions, syrups, and ointments. Plantgums are made of polysaccharides that can be used invarious formulations and chemical changes toimprove their properties [H Zaigham et al., 2019;].Researchers are actively attempting to develop a widerange of novel synthetic and semisyntheticcompounds from natural resources that are incrediblybeneficial to humans and animals.
The bioactive compounds derived from plant gum canbe extracted using current technological advances.Moringa oleifera is a widely distributed plant speciesused for medicinal purposes. oleifera comes underthe Moringaceae family and is fast-growing, droughttolerant,and readily adapted to various habitats andagricultural systems. The plant is native tonortheastern India and is commonly found in tropicaland subtropical regions [SJS Flora and V Pachauri,2011;]. In the Indian vegetable industry, it holds adistinct and coherent stance. M. oleifera has beenused as a food additive because of its high nutritionalcontent and easy digestion of proteins,minerals, vitamins, and carotenoids [JW Fahey,2005; K Maheshwari et al., 2014; J Mehta et al.,2011].
Pharmaceuticals based on metals, polymers,liposomes, and oxide
nanoparticles are beingresearched for their therapeutic potential in
manydiseases, including cancer [O C Farokhzad et al.,2006;]. Metal nanoparticle
synthesis has emerged asan essential branch of nanotechnology, with agrowing
commercial demand for NPs due to theirnumerous applications. Researchers have
beeninterested in AgNPs because of their uniqueproperties. In this research,
AgNPs have beencharacterized as antibacterial agents. Silver'santibacterial
action is magnified in the form of NPsdue to the increased number of NPs per
unit area(increase in area/surface/volume ratio) [M Araujo etal., 2020;]. In
the present investigation, Moringaoleifera gum (MOG) was collected, and its
physicalproperties and phytochemical composition wereanalyzed. The green
production and characterizationof AgNPs from M. oleifera gum were then carried
oututilizing UV-spectroscopic analysis and SEM. Severalstudies have reported
that M. oleifera plant parts suchas leaves, stems, and seeds have shown suitableantibacterial
activities [S Gupta et al., 2018;].However, because there has been no
previousresearch on M. oleifera gum, the current work focuseson the
antimicrobial characteristics of AgNPsgenerated from M. oleifera gum.
Reference
Zaigham H, Tauheed A,
Ali A. 2019. Recent trend in traditional medicine dosage form and present
status of Unani and Ayurvedic Medicine. International Journal of Pharmaceutical
Sciences and Research 10(4), 1640-1649.
Flora SJS, Pachauri V. 2011.Moringa
(Moringaoleifera) seed extract and the prevention of oxidative stress. In:
Preedy, VR, Watson, RR, Patel, VB. (Eds.), Nuts and Seeds in Health and Disease
Prevention. Academic Press, San Diego 92, 775–785.
Fahey JW. 2005. Moringa
oleifera: A Review of the Medical Evidence for Its Nutritional, Therapeutic,
and Prophylactic Properties. Part 1. Trees Life J 1, 15.
Maheshwari K, Yadav RK,
Malhotra J, Dhawan NG, Mohan L. 2014. Fascinating Nutritional,
Prophylactic, Therapeutic and Socio-Economic Reconcile Attributable to Drum
Stick Tree (Moringa oleifera Lam.). Global journal of medical research.
Pharma, Drug Discovery, Toxicology & Medicine 14, 11-22.
Mehta J, Shukla A,
Bukhariya V, Charde R, 2011. The Magic Remedy of Moringaoliferia: An
Overview. International Journal of Biomedical and advance research 2, 215-227.
Farokhzad OC, Cheng JJ,
Teply BA, Sherifi I, Jon S, Kantoff PW, Richie JP, Langer R. 2006.
Targeted nanoparticle aptamerbioconjugates for cancer chemotherapy in vivo.
Proceedings of the National Academy of Sciences of the United States of
America 103, 6315–6320.
Araujo M, Moises das
Virgens Santana, Antonio do Nascimento Cavalcante, Livio Cesar Cunha Nunes,
Luiz Carlos Bertolino, Carla Adriana Rodrigues de Sousa Brito, Humberto
Medeiros Barreto, Carla Eiras. 2020. Cashew-gum-based silver nanoparticles
and palygorskite as green nanocomposites for antibacterial applications.
Materials Science & Engineering C. 115, 110927.
Gupta S, Rohit J,
Kachhwaha S, Kothari SL. 2018. Nutritional and medicinal applications of
Moringa oleifera Lam.—Review of current status and future possibilities.
Journal of Herbal Medicine 11, 1-11.
Kumar RS, Renuka R. 2019.
Isolation and Characterization of Moringa olifera Gum: A Novel
Sustained Release Polymer. Journal of Drug Delivery & Therapeutics 9(3), 484-486.
Jarald EE, Sharma
Sumati, Sheeja Edwin, Ahmad S, Patni S, Daud A. 2012. Characterization of
Moringa oleifera Lam. Gum to establish it as a Pharmaceutical Excipient. Indian
Journal of Pharmaceutical Education and Research 46(3).
Harborne JB. 1998.
Textbook of Phytochemical Methods. A Guide to Modern Techniques of Plant
Analysis. 5th Edition, Chapman and Hall Ltd, London 21, 72.
Kokate CK. 2005.
Pharmacognosy” edition thirtieth published by Nirali Prakashan Pune 181, 186.
Shanmugavel G,
Prabakaran K, George. 2018. B Evaluation of phytochemical constituents
of Moringa oleifera (lam.) Leaves collected from Puducherry region,
South India, International Journal of Zoology and Applied Biosciences 3(1).
Chrzczanowicz J, Gawron
A, Zwolinska A, de Graft-Johnson J, Krajewski W, Krol M, Markowski J, Kostka T,
Nowak D. 2008. Simple method for determining human serum 2,
2-diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging activity–possible
application in clinical studies on dietary antioxidants. Clinical Chemical
Laboratory Medicine 46(3), 342-349 p.
Narenkumar J, Parthipan
P, Madhavan J, Murugan K, Marpu SB, Suresh AK, Rajasekar A. 2018.
Bioengineered silver nanoparticles as potent anti-corrosive inhibitor for mild
steel in cooling towers. Environmental Science and Pollution Research 25(6), 5412-5420
p.
Panda D, Si S, Swain S,
Kanungo SK, Gupta R. 2006. Preparation and evaluation of gels from the gum
of Moringa oleifera. Indian Journal of Pharmaceutical Sciences 68(6), 777780.
M Dekker. 2002.
“Edward MR: Modern Pharmaceutics”. New York. 287, 298.
Nep EI, Conway BR. 2010.
Characterization of Grewia gum, a potential pharmaceutical excipient. Journal
of Excipients and Food Chemicals 1, 30–40.
Somboonpanyakul P, Wang
Q, Cui W, Barbut S, Jantawat P. 2006.Malva nut gum.(Part I): Extraction
and physicochemical characterization. Carbohydr. Polym 64, 247–253.
Vinod VTP, Sashidhar
RB, Suresh K I, Rao B R, Saradhi UVR, Rao TP. 2008. Morphological, Physico-chemical
and structural characterization of gum kondagogu (Cochlospermumgossypium): A
tree gum from India. Food Hydrocolloids 22, 899–915.
Nussinovitch A. 2009.
Plant gum exudates of the world: sources, distribution, properties, and
applications. CRC Press. http://dx.doi.org/10.1201/9781420052244.
Mohammed FAA. 2015. Antioxidants
composition of moringa (Moringa oleifera lam) in different plant
organs (Doctoral dissertation).
Abdulkarim SM, Long K, Lai
OM, Muhammad SKS, Ghazali HM. 2005. Some Physico-chemical properties
of Moringa oleifera seed oil extracted using solvent and aqueous
enzymatic methods, Food Chemistry 93, 253–263.
Aviara NA, Power PP,
Abbas T. 2013. Moisture-dependent physical properties of Moringa
oleifera seed relevant in bulk handling and mechanical processing.
Industrial Crops and Products 42, 96–104.
Mohsenin NN. 1986. Physical
Properties of Plant and Animal Materials. Taylor and Francis, New York.
Goldstein IJ, Hay GW,
Lewis BA, Smith F. 1965. Controlled Degradation of Polysaccharides by
Periodate Oxidation, Reduction, and Hydrolysis, in Methods In Carbohydrate
Chemistry, ed. R L Whistler, J N BeMiller and M L
Wolfrom, Academic Press, New York. 5, 361–370.
Raja W, Bera K, Ray
B. 2016. Polysaccharides from Moringaoleifera gum:
structural elements, interaction with β-lactoglobulin and antioxidative
activity. RSC Advances 6(79), 75699–75706.
Siddhuraju P, Becker K. 2003.Antioxidant
Properties of Various Solvent Extracts of Total Phenolic Constituents from
Three Different Agroclimatic Origins of Drumstick Tree (Moringa oleifera Lam.)
Leaves, Journal of Agricultural and Food Chemistry 51(8), 2144–2155.
Luqman S, Srivastava S,
Kumar R, Maurya AD, Chanda D. 2012. Experimental Assessment
of Moringa oleifera Leaf and Fruit for Its Antistress, Antioxidant,
and Scavenging Potential Using In Vitro and In Vivo Assays. Evidence-based
complementary and alternative medicine:e CAM, 519084.
Devendra BN, Srinivas
N, Prasad VSSL. Talluri Warna Latha PS. 2011. Antimicrobial activity
of Moringa oleifera lam., leaf extract, against selected bacterial and
fungal strains, International Journal of Pharma and Bio Sciences 2(3), 13-18.
Elgamily H, Moussa A,
Elboraey A, El-Sayed H, Al-Moghazy M, Abdalla A. 2016.
Microbiological Assessment of Moringa oleifera Extracts and Its
Incorporation in Novel Dental Remedies against Some Oral Pathogens. Open
access Macedonian journal of medical sciences 4, 585–590.
Oluduro AO. 2012.
Evaluation of Antimicrobial properties and nutritional potentials of Moringa
oleifera Lam. leaf in South-Western Nigeria, Malaysian Journal of
Microbiology 8(2), 59-67.
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